IntermediateEvidence: Grade Bcognition

Neuro-Regen Stack — Long-Term Brain Optimisation

A three-compound protocol targeting neuroregeneration and long-term cognitive performance. Lion's Mane stimulates NGF and new neural connections; Bacopa Monnieri consolidates memory and strengthens existing synapses; Alpha-GPC provides the acetylcholine substrate for both. Designed for knowledge workers, high performers, and anyone seeking neuroprotection against age-related cognitive decline.

3 steps·3 compounds·Published March 1, 2026

Daily Schedule

Timing and dosage for each step

08:00 AM

300 mg

On empty stomach. Provides acetylcholine substrate for cognitive work throughout the morning.

08:30 AM

1000 mg

With breakfast. Full-spectrum fruiting body extract (≥25% beta-glucans). Effects build over 2–4 weeks.

01:00 PM

300 mg

With lunch (fat-containing meal improves bacoside absorption). Do not take in the evening — can cause mental alertness.

Concept: Three Levels of Cognitive Support

The Neuro-Regen Stack operates on three levels simultaneously:

  1. Neurogenesis (Lion's Mane) — literally grows new neural connections through NGF stimulation
  2. Memory consolidation (Bacopa) — strengthens existing synapses and improves signal transmission between neurons
  3. Neurotransmitter substrate (Alpha-GPC) — supplies choline for acetylcholine synthesis, required for both of the above

An analogy: Lion's Mane builds new roads, Bacopa makes them more efficient, Alpha-GPC provides the fuel for traffic to flow.

Time Horizon

This is a long-term investment protocol:

  • Weeks 1–2: Possible focus improvement from Alpha-GPC (fast-acting)
  • Weeks 4–6: Early memory improvement signs from Lion's Mane
  • Weeks 8–12: Full Bacopa effect on long-term memory
  • Month 4+: Cumulative neuroprotective effect

Who This Protocol Is For

  • Knowledge workers: developers, researchers, founders
  • People over 40 with early signs of cognitive decline
  • Students on extended projects (long study cycles)
  • Prevention of age-related neurodegenerative changes

Critical Note on Lion's Mane Quality

Avoid products made from mycelium on grain — this is effectively dried grain with negligible active compound content. Always choose fruiting body extract with a stated beta-glucan percentage (≥25%).