Research Blog
125 evidence-graded articles. Reviews, protocol guides, and study breakdowns — every piece is Oxford-scale rated and PubMed referenced.
Estrogen Metabolism: DIM and Calcium-D-Glucarate Explained
Oestrogen is not simply produced and then gone. It is hydroxylated, conjugated, excreted — and, if gut bacteria intervene, reabsorbed and sent round again. Two supplements claim to work that pipeline: one moves the biomarker but no outcome, the other was never tested in humans.
The Menopause Transition Protocol: Building Non-Hormonal Support in Layers
Most menopause stacks are assembled in the order the products are marketed: hot-flush herb first, everything else later or never. Building in evidence order inverts that entirely — and produces a protocol where the mandatory layer is the one you will never feel working.
Perimenopause Supplements: What the Evidence Actually Supports
Most perimenopause supplement advice is written as if the question were which bottle to buy. The evidence answers a different question first: what actually works, what only looks like it works, and why the one intervention with the clearest case is the one nobody feels.
The ApoB Optimization Protocol: Bergamot + Berberine + Omega-3
A supplement protocol built around one number: ApoB, the particle count that predicts cardiovascular events. Bergamot inhibits synthesis, berberine upregulates LDL receptors, EPA-forward omega-3 covers triglycerides — with realistic effect sizes and a 12-week verdict built in.
Nattokinase and Fibrinolysis: The Clot-Dissolving Enzyme
Nattokinase is the only common supplement that acts on the clotting side of cardiovascular risk — degrading fibrin directly and inactivating PAI-1. The acute human data are real. The long-term data include a rigorous null trial almost nobody cites. Both halves of that story matter.
ApoB and Lp(a): The Cardiovascular Markers That Matter
LDL-C is a decent proxy, but the arteries count particles, not cholesterol mass. ApoB measures every atherogenic particle directly, and Lp(a) is the inherited risk most people have never tested. What each marker means, the targets, and what actually moves them.
The Inflammation Resolution Stack: Curcumin + Boswellia + SPMs
Most anti-inflammatory stacks are three polyphenols doing the same job. This one is built by mechanism: substrate, suppression, the leukotriene branch, and the resolution programme itself — with an honest account of where the evidence stops.
Specialized Pro-Resolving Mediators (SPMs): Beyond Omega-3
Inflammation does not simply fade when the trigger disappears — it is switched off by a dedicated family of molecules built from EPA and DHA. That discovery reframed chronic inflammation as failed resolution. The supplements it produced are a more complicated story.
Curcumin Bioavailability: Why Form Matters More Than Dose
Two bottles both say 1000 mg. One delivers a fraction of what the other does into your bloodstream. Curcumin is the supplement where the milligram figure on the label is the least informative number on it.
The Thyroid Support Protocol: Selenium + Iodine + Zinc + Tyrosine
Four nutrients, in order of how much evidence stands behind them — and an honest account of what a supplement stack can and cannot do for a thyroid. Doses, timing, the labs to run first, and the one step most people should skip.
Subclinical Hypothyroidism: An Evidence-Based Approach
A mildly raised TSH with a normal free T4 is one of the most common abnormal results in medicine — and one of the most over-treated. Two large pieces of evidence explain why the reflex to prescribe levothyroxine mostly does not survive scrutiny.
Selenium and Iodine: The Thyroid Mineral Pair
One mineral is the raw material thyroid hormone is built from. The other runs the enzymes that activate it and protect the gland while it works. Taking either one without the other is how well-intentioned thyroid support goes wrong.