Research Blog
134 evidence-graded articles. Reviews, protocol guides, and study breakdowns — every piece is Oxford-scale rated and PubMed referenced.
The Hair Retention Protocol: Topical and Systemic Support Built in Evidence Order
Most hair protocols are assembled in the order the products are sold: a DHT-blocker blend first, a diagnosis never. Building in evidence order inverts that — and produces a protocol whose most important layer contains no supplement at all, and whose strongest tier is the one it hands you to.
Rosemary Oil vs Minoxidil: What the 2015 Trial Actually Showed
One trial, one centre, one hundred patients, and a decade of social media built on it. The 2015 rosemary-versus-minoxidil study is real and its result is honestly reported. What it cannot support is the sentence the internet took from it — and the gap between the two is the whole story.
Hair Loss Science: DHT, Follicles and What Actually Works
Most hair-loss advice starts with a product. The biology starts with a receptor some follicles inherit and others do not, an enzyme that concentrates where balding happens, and a growth cycle that shortens until the hair is too fine to see. That sequence is what makes the evidence table readable.
The Insulin Sensitivity Stack: Berberine + Inositol + ALA + Chromium
Most blood-sugar stacks are assembled from the shelf inward: chromium because it is cheap, ALA because it is an antioxidant, berberine last. Building in evidence order inverts that — and produces a protocol where the first thing you buy is a blood test and the last thing you buy is optional.
Alpha-Lipoic Acid: Glucose Disposal, Neuropathy and the Trials That Matter
Alpha-lipoic acid is a German prescription drug for diabetic neuropathy and an American supplement for blood sugar. The neuropathy evidence is real and dose-specific; the glucose evidence is a 1999 pilot and a pair of disagreeing meta-analyses. The autoimmune hypoglycaemia risk is on neither label.
Myo-Inositol: The Insulin Sensitiser for PCOS and Beyond
Myo-inositol has the best supplement evidence in PCOS — cycles, insulin, androgens, all against placebo and against metformin. It also has a retracted founding trial, a null pregnancy trial, and no outcome data outside the ovary. Both halves belong in the same article.
The Male Vitality Protocol: Fertility and Sexual Function Beyond Testosterone
Most 'male vitality' stacks are testosterone stacks with a different label. This one is built for a different outcome set — sperm count, motility, morphology, libido and erections — and for the fact that sperm ejaculated today began developing eleven weeks ago, so nothing is judged before week 12.
When Lifestyle Isn't Enough: The TRT Decision Framework
There is a point past which sleep, body fat and supplements stop being the answer, and a man with symptoms and a persistently low number needs a diagnosis. What that requires, what TRT has been shown to do in randomised trials, and why it is wrong for a man who wants children.
Natural Testosterone Optimization: What Actually Works (and What Doesn't)
Most testosterone advice is a product list. The trial evidence orders things differently: the largest effects belong to sleep and body fat, the next tier is correcting a measured deficiency, and the supplements with real human data sit last — small, real, and easily outweighed by the tiers above.
Estrogen Metabolism: DIM and Calcium-D-Glucarate Explained
Oestrogen is not simply produced and then gone. It is hydroxylated, conjugated, excreted — and, if gut bacteria intervene, reabsorbed and sent round again. Two supplements claim to work that pipeline: one moves the biomarker but no outcome, the other was never tested in humans.
The Menopause Transition Protocol: Building Non-Hormonal Support in Layers
Most menopause stacks are assembled in the order the products are marketed: hot-flush herb first, everything else later or never. Building in evidence order inverts that entirely — and produces a protocol where the mandatory layer is the one you will never feel working.
Perimenopause Supplements: What the Evidence Actually Supports
Most perimenopause supplement advice is written as if the question were which bottle to buy. The evidence answers a different question first: what actually works, what only looks like it works, and why the one intervention with the clearest case is the one nobody feels.