Research Blog
113 evidence-graded articles. Reviews, protocol guides, and study breakdowns — every piece is Oxford-scale rated and PubMed referenced.
The Liver Optimization Protocol: NAC + TUDCA + Milk Thistle
Your liver isn't clogged and doesn't need flushing. It needs substrate for reactions it already runs — which is why the useful protocol looks nothing like a detox tea and everything like precursor supply.
TUDCA: The Bile Acid for Liver and Mitochondria
TUDCA has one of the most elegant mechanisms in the supplement world — and one of the most instructive recent failures. Here's what a chemical chaperone actually does, what the human trials found, and why the ALS story matters to anyone buying it.
NAC and Glutathione: The Master Antioxidant System
Glutathione is the antioxidant your cells actually run on, and it falls with age. The interesting part isn't whether to raise it — it's that the trials with the best results didn't use glutathione, or even NAC alone.
The Bone & Arterial Health Stack: D3 + K2 + Magnesium + Boron
Four cheap, well-tolerated nutrients that solve one problem together: getting calcium into bone and out of arteries. Here's how D3, K2, magnesium, and boron divide the labour — and the order to add them in.
Vitamin D Dosing: Why Most People Get It Wrong
The mistake isn't the dose — it's dosing to a number instead of a blood level. Here's what the big trials actually showed, the target range that matters, and the two cofactors that decide whether your vitamin D works at all.
Vitamin K2 (MK-7): The Calcium Traffic Controller
Calcium builds bone or stiffens arteries depending on where it lands — and vitamin K2 is the switchman. Here's how MK-7 activates the proteins that route calcium, what the 3-year trials showed, and the one drug it must never be mixed with.
The Ultimate Longevity Stack 2026: Evidence-Tiered Recommendations
Most longevity stacks are a shopping list with no hierarchy. This one is sorted by the strength of human evidence — two compounds that earn a permanent place, four that are reasonable bets, and a top tier that is honest experimentation. Plus what we deliberately left out.
The Physician's Longevity Supplement Framework: An Evidence Tiering
How a careful clinician actually decides what belongs in a longevity stack — not a list of favourites, but a repeatable filter: evidence strength, risk-benefit at the individual level, and whether a biomarker can tell you it's working. The framework outlives any single compound.
A Data-Driven Longevity Blueprint: What Extreme Optimizers Actually Do
Maximalist longevity regimens run on a hundred supplements, continuous biomarker tracking, and an epigenetic clock readout. We separated the parts that hold up under evidence from the parts that are measurement theatre — and found the expensive tier is rarely the one doing the work.
The Vision Longevity Protocol: AREDS2, Astaxanthin & Saffron
A layered eye-supplement strategy sorted honestly by evidence: a macular-pigment foundation everyone can justify, an antioxidant middle layer for screen strain, and an experimental retinal-function tier — with AREDS2 kept where it belongs, for people who actually have macular degeneration.
AREDS2 Formula: What the Largest Eye Health Trial Showed
AREDS2 is the study every 'eye health' supplement leans on — and almost every label misreads it. It slowed progression in people who already had intermediate macular degeneration. It did nothing for healthy eyes, and it quietly proved beta-carotene was the wrong ingredient.
Lutein and Zeaxanthin: Why Every Computer User Should Supplement
If you stare at screens all day, the two carotenoids your retina concentrates into macular pigment are the best-evidenced thing you can supplement for your eyes. Here's what they actually do — filter blue light, sharpen contrast, speed glare recovery — and what they don't.