The Bio-Clock Reset Protocol
The most comprehensive biological clock reset protocol available outside clinical settings. Combines Professor Khavinson's original dual-peptide longevity protocol (Epithalon + Thymalin) with Magnesium L-Threonate for sleep and pineal support. Targets the two master regulators of biological ageing - the neuroendocrine system and the immune system - simultaneously, in the tradition of the landmark St. Petersburg longevity research.
Daily Schedule
Timing and dosage for each step
08:00 AM
10 mg
Subcutaneous injection. Day 1 of 10-day cycle. Reconstitute with 1ml bacteriostatic water. Rotate injection sites.
08:00 AM
10 mg
Subcutaneous injection, same session as Epithalon. The Khavinson dual-peptide protocol - both given simultaneously each morning of the cycle.
09:00 PM
2000 mg
2000mg Magtein (Magnesium L-Threonate) 1-2 hours before sleep throughout the cycle. Supports pineal melatonin synthesis and sleep architecture during the active peptide cycle.
Protocol Overview
The Bio-Clock Reset Protocol is built on over 30 years of clinical research from the St. Petersburg Institute of Bioregulation and Gerontology. Professor Vladimir Khavinson's hypothesis: biological ageing is governed by two master systems -- the neuroendocrine system (regulated by the pineal gland) and the immune system (regulated by the thymus). Both undergo progressive decline from early adulthood.
- Epithalon targets the neuroendocrine system: restores pineal function, normalises melatonin production, activates telomerase, and reduces oxidative damage in neural tissue
- Thymalin targets the immune system: restores thymic function, normalises T-cell production, and reverses immunosenescence
- Magnesium L-Threonate supports the protocol: crosses the blood-brain barrier to support pineal function, improves sleep architecture for optimal hormonal secretion, and provides the magnesium required for melatonin synthesis
The 10-Day Cycle Structure
Run both peptides simultaneously for 10 consecutive days. This is the original Khavinson protocol timing, validated across multiple clinical studies.
Active cycle (Days 1-10):
- Morning: Epithalon 10mg SC + Thymalin 10mg SC
- Evening: Magnesium L-Threonate 2000mg
Rest period: Minimum 3-4 months before repeating.
Annual schedule: Most practitioners run 2 cycles per year -- spring (March-April) and autumn (September-October).
Who This Protocol Is For
- Adults over 40 seeking a systematic anti-ageing intervention
- Individuals with evidence of immune decline (frequent illness, poor vaccine response)
- Those with disrupted circadian rhythm or significantly impaired sleep quality
- Advanced biohackers who have already optimised foundational protocols (NMN, resveratrol, lifestyle)
Important Notices
Both Epithalon and Thymalin are research peptides. Not approved by the FDA or EMA for human use. All information is for educational purposes only. Consult a physician before starting any injectable peptide protocol.
Evidence Context
The 12-year longitudinal study (Khavinson, 2003) in 266 elderly patients demonstrated a 28% reduction in mortality in the combined Epithalon + Thymalin group versus controls. This is the strongest long-term human longevity dataset for any peptide protocol currently available outside pharmaceutical trials.