Protocol Hub
Evidence-graded stacking protocols. Each protocol lists the compounds used, their daily schedule, and the evidence behind the combination.
The Bio-Clock Reset Protocol
The most comprehensive biological clock reset protocol available outside clinical settings. Combines Professor Khavinson's original dual-peptide longevity protocol (Epithalon + Thymalin) with Magnesium L-Threonate for sleep and pineal support. Targets the two master regulators of biological ageing - the neuroendocrine system and the immune system - simultaneously, in the tradition of the landmark St. Petersburg longevity research.
3 steps · 3 compounds
View protocol →Deep Sleep Architect
A research-backed evening protocol targeting both sides of the sleep equation: cortisol reduction and brain magnesium optimisation. Ashwagandha KSM-66 lowers the stress hormone that delays sleep onset; Magnesium L-Threonate crosses the blood-brain barrier to improve sleep architecture and REM quality. Suitable for anyone with elevated evening stress, poor sleep quality, or frequent night waking.
2 steps · 2 compounds
View protocol →The Dopamine Reset Stack — 9-Me-BC Protocol
A protocol for restoring dopaminergic function after stimulant overuse, burnout, or receptor downregulation. 9-Me-BC promotes dopaminergic neuron proliferation and inhibits MAO-B; Lion's Mane supports neuroplasticity; Selank manages stimulatory side effects. For experienced biohackers only.
3 steps · 3 compounds
View protocol →The Flow State Stack
A precision cognitive performance stack combining Russia's two most studied nootropic peptides with a cholinergic foundation. Semax provides dopaminergic drive and BDNF-mediated neuroplasticity; Selank provides GABAergic calm and anxiety reduction; Alpha-GPC provides the acetylcholine substrate both peptides work on. The result is a sustained, clear-headed flow state without stimulant side effects - designed for knowledge workers, creatives, and high performers.
3 steps · 3 compounds
View protocol →Foundational Longevity Stack
The most widely adopted evidence-based longevity stack, built around NAD+ restoration and sirtuin pathway activation. Suitable for adults over 35 seeking a science-backed starting point for longevity supplementation.
3 steps · 3 compounds
View protocol →The Gut Barrier Protocol — BPC-157 + KPV
A targeted peptide protocol combining BPC-157 and KPV for comprehensive gut barrier restoration. BPC-157 rebuilds mucosal structure via growth factor pathways; KPV suppresses intestinal inflammation via MC1R signalling. Designed for leaky gut, IBD, post-antibiotic dysbiosis, and SIBO recovery.
4 steps · 2 compounds
View protocol →Hormonal Optimization Stack
A foundational stack for natural testosterone optimisation without pharmaceuticals. Tongkat Ali directly supports LH and free testosterone via SHBG reduction; Ashwagandha addresses the cortisol side of the equation. Together they target both the production and suppression of testosterone — the most evidence-backed supplement combination for hormonal balance in men over 35.
2 steps · 2 compounds
View protocol →The Lean Mass Preservation Stack — GLP-1 + Growth Hormone Protocol
A protocol combining a GLP-1/GIP/glucagon triple agonist (retatrutide) with growth hormone secretagogues (ipamorelin + CJC-1295) to achieve aggressive fat loss while preserving lean mass. Addresses the primary limitation of GLP-1 therapy: muscle catabolism during caloric restriction.
3 steps · 3 compounds
View protocol →The Metabolic Optimizer
An advanced metabolic reprogramming protocol for practitioners with significant biohacking experience. Combines mitochondrial DNA signalling (MOTS-c), direct AMPK activation (AICAR), and NAD+ restoration (NMN) to comprehensively address cellular energy metabolism. Targets the same pathways as caloric restriction and endurance exercise at the molecular level. Requires blood glucose monitoring and is not appropriate for beginners.
3 steps · 3 compounds
View protocol →The Ultimate Mitochondrial Matrix — SS-31 + MOTS-c + NAD+
A comprehensive mitochondrial restoration protocol layering SS-31 (inner membrane repair), MOTS-c (biogenesis activation), NMN (NAD+ substrate), and PQQ (PGC-1α stimulation). Designed for chronic fatigue, exercise performance decline, and mitochondrial age-related dysfunction. The order of administration is critical.
4 steps · 4 compounds
View protocol →The mTOR Sabbatical — Rapamycin + Acarbose Protocol
The evidence-based longevity protocol centred on pulsed mTOR inhibition via weekly rapamycin. Modelled on protocols used by longevity physicians including Peter Attia. Combines rapamycin's mTORC1 inhibition with complementary autophagy support (spermidine) and NAD+ restoration (NMN). Requires physician prescription and monitoring.
3 steps · 3 compounds
View protocol →Neuro-Regen Stack — Long-Term Brain Optimisation
A three-compound protocol targeting neuroregeneration and long-term cognitive performance. Lion's Mane stimulates NGF and new neural connections; Bacopa Monnieri consolidates memory and strengthens existing synapses; Alpha-GPC provides the acetylcholine substrate for both. Designed for knowledge workers, high performers, and anyone seeking neuroprotection against age-related cognitive decline.
3 steps · 3 compounds
View protocol →The Sexual Wellness Protocol
A three-layer protocol addressing sexual wellness from the ground up: Zinc builds the hormonal foundation; PT-141 activates central arousal pathways via melanocortin receptors; Oxytocin deepens emotional connection and amplifies the bonding dimension of intimacy. The only evidence-backed supplement stack that addresses both the physiological and psychological dimensions of sexual function simultaneously.
3 steps · 3 compounds
View protocol →The Wolverine Stack — Elite Recovery Protocol
The most powerful peptide protocol for soft tissue injury recovery. Combines BPC-157's targeted local healing with TB-500's systemic cell mobilisation. Named for its near-miraculous regenerative capacity. Used by athletes, practitioners, and biohackers for tendon, ligament, and muscle repair.
3 steps · 2 compounds
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