Semax vs Selank
Side-by-side comparison of evidence grade, dosage, safety, and stacking compatibility.
Combined: Synergistic ✦— Classic Russian peptide duo. Semax for focus and drive; Selank for calm. Ideal f…
Overview
A synthetic heptapeptide analogue of ACTH(4-7) developed in Russia. Increases BDNF and NGF expression, enhances dopaminergic and serotonergic neurotransmission, and has demonstrated neuroprotective effects in stroke recovery. Fast-acting via nasal administration.
Summary
A synthetic heptapeptide analogue of tuftsin with anxiolytic, nootropic, and immunomodulatory properties. Developed in Russia as a dependence-free alternative to benzodiazepines. Reduces anxiety without sedation, enhances memory consolidation, and stabilises mood under stress.
Nootropic Peptide
Category
Anxiolytic Peptide
B
Evidence Grade
A = strongest
B
Tier B — Moderate
Safety Tier
A = safest
B winsTier A — Proven
Dosage
0.6 mg/day
Typical Dose
0.5 mg/day
0.3–1.2 mg
Low / High
0.25–1 mg
Intranasal spray, 1-2 drops per nostril. Morning or before cognitively demanding work. Avoid evening - stimulating.
Timing
Intranasal spray, 1-2 drops per nostril. Morning or evening. No stimulating effect - suitable for daytime or pre-sleep use.
2-4 weeks on, 1-2 weeks off. Tolerance develops with daily use.
Cycling
2-4 weeks continuous, then 1-2 weeks off. Minimal tolerance.
Goals & Use Cases
cognitionneuroprotectionstress-resiliencefocus
Primary Goals
stress-resiliencecognitionsleepfocus
Shared goals:cognitionstress-resiliencefocus
Safety Profile
- •Anxiety disorders - may exacerbate in some users
- •Pregnancy - insufficient data
- •Seizure disorders
Contraindications
fewer = safer
B wins- Pregnancy - insufficient data•
Regulatory Status
✓ Legal
Legal (US)
✓ Legal
✓ Legal
Legal (EU)
✓ Legal
Can you take Semax and Selank together?
Synergistic ✦
Classic Russian peptide duo. Semax for focus and drive; Selank for calm. Ideal for high-pressure work sessions.
Semax drives cognitive performance via dopaminergic/BDNF pathways. Selank manages anxiety and stress via GABAergic/serotonergic mechanisms. Selank balances Semax's stimulating edge.
Compare with other compounds