Resveratrol vs Fisetin
Side-by-side comparison of evidence grade, dosage, safety, and stacking compatibility.
Combined: Synergistic ✦— Both taken with fat for bioavailability. Can be co-administered on pulse dosing …
Polyphenol / Sirtuin Activator
Resveratrol
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VS
Senolytic / Polyphenol
Fisetin
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Overview
A polyphenolic stilbenoid found in red wine and grape skins that activates SIRT1 and AMPK pathways. Requires NAD+ co-factors for maximal sirtuin activation, making it synergistic with NMN.
Summary
A flavonoid found in strawberries with the most potent senolytic activity among all tested compounds. Selectively eliminates senescent cells that accumulate with age and drive systemic inflammation — the SASP effect.
Polyphenol / Sirtuin Activator
Category
Senolytic / Polyphenol
B
Evidence Grade
A = strongest
B
Tier A — Proven
Safety Tier
A = safest
Tier A — Proven
Dosage
500 mg/day
Typical Dose
500 mg/day
100–1000 mg
Low / High
100–1500 mg
Morning with breakfast containing fat (improves absorption 5-fold)
Timing
Pulse dosing: 500–1500mg/day for 2 consecutive days, once per month. Take with a fat-containing meal.
Continuous use acceptable; some protocols use 5-on/2-off
Cycling
Pulse protocol: 2 consecutive days per month. Not for daily use.
Goals & Use Cases
longevitycardiovascularanti-inflammatory
Primary Goals
longevitycellular-repairanti-inflammatory
Shared goals:longevityanti-inflammatory
Safety Profile
- •Blood-thinning medications (warfarin, aspirin) — may potentiate anticoagulant effect
- •Hormone-sensitive cancers (oestrogen-receptor positive)
- •Pregnancy — insufficient safety data
Contraindications
fewer = safer
B wins- Blood-thinning medications (fisetin inhibits platelet aggregation)•
- Pregnancy — insufficient safety data•
Regulatory Status
✓ Legal
Legal (US)
✓ Legal
✓ Legal
Legal (EU)
✓ Legal
Can you take Resveratrol and Fisetin together?
Synergistic ✦
Both taken with fat for bioavailability. Can be co-administered on pulse dosing days.
Compare with other compounds