Ipamorelin vs CJC-1295 (without DAC)

Side-by-side comparison of evidence grade, dosage, safety, and stacking compatibility.

Combined: Synergistic ✦— The standard GH optimisation stack. Inject both simultaneously before sleep. Mos…

Growth Hormone Secretagogue

Ipamorelin

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GHRH Analogue

CJC-1295 (without DAC)

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Overview

A selective growth hormone secretagogue peptide that stimulates GH release from the pituitary with the highest selectivity of any GHRP - without raising cortisol, prolactin, or ACTH. The cleanest GH-stimulating peptide available, typically paired with a GHRH analogue (CJC-1295) for synergistic GH pulse amplification.

Summary

A modified analogue of Growth Hormone Releasing Hormone (GHRH) that stimulates the pituitary to produce and release growth hormone. The 'without DAC' form produces physiological GH pulses rather than sustained elevation, making it the preferred variant for anti-ageing and recovery protocols. Always used alongside a GHRP (typically Ipamorelin) for synergistic GH amplification.

Growth Hormone Secretagogue

Dosage

0.2 mg/day

Typical Dose

0.1 mg/day

0.1–0.3 mg

Low / High

0.05–0.2 mg

Subcutaneous injection before sleep (maximises natural GH pulse during slow-wave sleep). Can also be dosed pre-workout. Always inject fasted - insulin blunts GH response.

Timing

Subcutaneous injection before sleep, fasted. Must be injected fasted - glucose and insulin blunt GHRH-stimulated GH release by up to 70%.

12-16 weeks on, 4-8 weeks off to prevent receptor desensitisation.

Cycling

12-16 weeks on, 4-8 weeks off.

Goals & Use Cases

recoveryperformancesleepanti-aging

Primary Goals

recoveryperformancesleepanti-aging

Shared goals:recoveryperformancesleepanti-aging

Safety Profile

•Active cancer or cancer history - GH promotes IGF-1 which is mitogenic
•Diabetic retinopathy
•Pregnancy
•Competitive athletes - WADA prohibited substance

Contraindications

fewer = safer

Active cancer - IGF-1 elevation is mitogenic•
Diabetic retinopathy•
Pregnancy•
Competitive athletes - WADA prohibited•

Regulatory Status

✓ Legal

Legal (US)

✓ Legal

Legal (EU)

✓ Legal

Can you take Ipamorelin and CJC-1295 (without DAC) together?

Synergistic ✦

The standard GH optimisation stack. Inject both simultaneously before sleep. Most practitioners use 100-200mcg of each.

Ipamorelin mimics ghrelin at the GH secretagogue receptor (GHSR), triggering GH release. CJC-1295 is a GHRH analogue that simultaneously stimulates GHRH receptors. Activating both receptor types simultaneously produces synergistic GH pulse amplification - 3-5x greater GH release than either peptide alone.

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Compare with other compounds

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