Epithalon (Epitalon) vs NMN (Nicotinamide Mononucleotide)
Side-by-side comparison of evidence grade, dosage, safety, and stacking compatibility.
Combined: Synergistic ✦— NMN restores NAD+ for DNA repair; Epithalon activates telomerase for telomere ma…
Longevity Peptide
Epithalon (Epitalon)
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VS
NAD+ Precursor
NMN (Nicotinamide Mononucleotide)
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Overview
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland extract Epithalamin. The only peptide with published human data on telomere elongation. Considered one of the most significant longevity compounds in peptide research.
Summary
A nucleotide precursor that replenishes cellular NAD+ levels, which decline significantly with age. Among the most-researched longevity compounds with human clinical trial data.
Longevity Peptide
Category
NAD+ Precursor
C
Evidence Grade
A = strongest
B winsB
Tier B — Moderate
Safety Tier
A = safest
B winsTier A — Proven
Dosage
10 mg/day
Typical Dose
500 mg/day
5–20 mg
Low / High
250–1000 mg
Subcutaneous injection once daily for 10-20 day cycles. Typical: 10mg/day for 10 days, 2-3x per year.
Timing
Morning, fasted or with a light breakfast
10-20 day cycle, 2-3x per year.
Cycling
5 days on, 2 days off (optional cycling protocol)
Goals & Use Cases
longevitysleepanti-aging
Primary Goals
longevityenergycellular-repair
Shared goals:longevity
Safety Profile
- •Active cancer (promotes cell proliferation via telomerase activation)
- •Autoimmune diseases — use with caution
Contraindications
fewer = safer
- Active cancer treatment (consult oncologist first)•
- Pregnancy or breastfeeding (insufficient safety data)•
Regulatory Status
✓ Legal
Legal (US)
✓ Legal
✓ Legal
Legal (EU)
✓ Legal
Can you take Epithalon (Epitalon) and NMN (Nicotinamide Mononucleotide) together?
Synergistic ✦
NMN restores NAD+ for DNA repair; Epithalon activates telomerase for telomere maintenance. Complementary longevity mechanisms — Epithalon during cycles, NMN daily.
Compare with other compounds