BeginnerEvidence: Grade Bsleep

Deep Sleep Stack

A four-compound layered sleep protocol targeting four independent mechanisms — brain magnesium (magnesium L-threonate), GABA-A modulation (apigenin), alpha-wave calm and reduced arousal (L-theanine), and core-temperature drop (glycine). Built for sleep onset and depth without sedative-hypnotic dependence.

4 steps·4 compounds·Published May 8, 2026

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EMA Notice — Research Purposes Only

This information is provided for scientific research purposes only in accordance with Regulation (EC) No 1924/2006. It does not constitute medical advice and should not be interpreted as an endorsement by the European Medicines Agency (EMA) or any national competent authority. Consult a qualified healthcare professional before use.

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Daily Schedule

Timing and dosage for each step

Evening

GlycineTier A

3000 mg

Dissolve in water 30-60 min before bed. Drops core body temperature to trigger sleep onset. Strongest individual sleep evidence — start here.

Evening

Magnesium L-ThreonateTier A

2000 mg

~144mg elemental magnesium. Brain-penetrant form; modulates NMDA and GABA-A. Foundation of the stack.

Evening

L-TheanineTier A

200 mg

Raises alpha-wave activity and lowers pre-sleep arousal. Best for a racing mind. No caffeine in the evening.

Evening

ApigeninTier A

50 mg

Binds the GABA-A benzodiazepine site for gentle anxiolysis. Absorbs better with a little dietary fat.